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Nonetheless, response data are accumulating for other less common mutations and therefore, our consensus opinion is that limiting testing to the 2 major mutations is no longer considered acceptable.

Patients previously treated with platinum combination chemotherapy may derive symptom control and survival benefit from docetaxel, pemetrexed, or epidermal growth factor receptor inhibitors.


PD dosing regimens for the simulations because for each dose and AUC t a different IC 50 and K tr value is defined.

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Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer.

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Thus, disruption of the EGFR signal transduction pathway is an ideal target for anticancer therapy.

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The important point is that the PFS and OS advantage seen in the Cappuzzo trial is largely driven by the EGFR wt patients who get a significant yet more modest benefit from maintenance EGFR TKI compared to the EGFR mutant population.


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